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REH Cells

Established from the peripheral blood of a 15-year-old North African girl with acute lymphoblastic leukemia (ALL at first relapse) in 1973; carries t(12;21) leading to ETV6-RUNX1 (TEL-AML1) fusion gene

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REH Cells

Mono-Mac-1 Cells Buy

Established from the peripheral blood of a 64-year-old man with acute monocytic leukemia (AML FAB M5) at relapse in 1985 following myeloid metaplasia; simultaneous sister cell line of MONO-MAC-6 (DSM ACC 124); cells are described to be less differentiated than MONO-MAC-6 and to support productive infection with HIV-1

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Mono-Mac-1 Cells Buy

Tumor Cells 697

Established from the bone marrow of a 12-year-old boy with acute lymphoblastic leukemia (cALL) at relapse in 1979; cells express BCL2, BCL3 and MYC mRNA; recently termed "EU-3" in the literature.

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Tumor Cells 697

TRP Channels

Transient receptor potential channels (TRP) are non-selective calcium permeant cation channel located mostly on the plasma membrane of numerous animal cell types. They are involved in osmotic sensitivity and mechano-sensitivity. The exposure to hypotonicity within the physiological range induces some TRP channels activation exhibiting an outward rectification. TRP channels can also be activated by heat, low pH, citrate and phorbol esters. The increase of intracellular Ca2+ potentiates TRP channel currents. TRP Channels play an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

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TRP Channels

Calcium Channels

Calcium channel have been well recognized as therapeutic targets for treating a number of diseases. However, the calcium channel class is considered to be underexploited due to the lack of reliable functional cell-based assays for high-throughput screening.

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Calcium Channels

Chloride Channels

Chloride Channels are a superfamily of poorly understood ion channels specific for chloride. Though the functions of CLC cytoplasmic domains are not fully characterized yet, their importance is illustrated by the pathologies resulting from their mutations. Voltage-gated chloride channels display a variety of important physiological and cellular roles that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups.

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Chloride Channels

In Vitro Metabolism

With extensive knowledge and experience in drug discovery, Creative Bioarray can provide standard, cost-effective in vitro metabolism services, including drug metabolic stability services and drug-drug interaction services to support your drug development process.

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In Vitro Metabolism

In Vitro Permeability and Transporters

Creative Bioarray provides a number of in vitro permeability and transporter assays to evaluate drug permeability and predict drug absorption and distribution, including Caco-2 permeability assay, MDCK permeability assay, Parallel artificial membrane permeability assay (PAMPA), and a panel of transporter assays on several of the most relevant transporters such as canine P-glycoprotein (P-gp), BCRP, BSEP, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

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In Vitro Permeability and Transporters

Physicochemical Characterization Assays

Creative Bioarray provides Physicochemical Characterization Assays to help customers accurately evaluate compounds' physicochemical properties such as solubility and stability, Reducing drug development difficulties.

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Physicochemical Characterization Assays

Frozen Tissue

Frozen tissues samples have been widely used in medical research for cancer and other diseases to examine cell morphology, disease status, intracellular and intercellular communication, as well as biopsy tissue sections.

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Frozen Tissue

Antibody Selection and Optimization

Antibodies can often be used in multiple assays, but they do not perform equally well in all assays. This is particularly true for immunohistochemistry (IHC). IHC has now become an indispensable assay and is consistently performed in anatomic pathology to give specific diagnosis and subclassification of neoplasms.

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Antibody Selection and Optimization

In Situ Hybridization

In situ hybridization is a technique for detecting the expression pattern of a particular gene sequence in cells or tissues using a complimentary sequence known as a probe. The probe is typically labeled with a fluorochrome or an enzyme, so it can be detected either by using a fluorescent microscope or with a bright field microscope.

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In Situ Hybridization

C57BL/6 Mouse Liver Kupffer Cells

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C57BL/6 Mouse Liver Kupffer Cells

Kupffer Cells

Kupffer cells are resident liver macrophages and play a critical role in maintaining liver function. Under physiological conditions, they are the first innate immune cells that protect the liver from bacterial infection. Under pathological conditions, they are activated by different components and can differentiate into M1-like (classical) or M2-like (alternative) macrophages. The metabolism of classical or alternative activated Kupffer cells will determine their function in liver damage. Special function and metabolism of Kupffer cells suggest that they are an attractive target for the treatment of liver inflammation and related diseases, including cancer and infectious diseases.

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Kupffer Cells

Keratinocytes

Keratinocyte Cells are the most common skin cells, 90% of them are located on the out layer of the skin. The Keratinocyte Cells work as a barrier that protect the under skin layer tissue and nerves. This barrier can be found everywhere in our body, such as skin, hair, and nails, they are all made by keratin protein which produced by Keratinocyte Cells. Creative bioarray provides multiple types of Keratinocyte Cells growth media such as Human Keratinocyte Stem Cell Media, Epidermal Keratinocyte 3D Prime Medium, Defined, Epidermal Keratinocyte Medium, Defined, Calcium Free and PCT Epidermal Keratinocyte Medium, Low BPE, Calcium Free etc.

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Keratinocytes

Human Epidermal Keratinocytes

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Human Epidermal Keratinocytes

Human Primary Hepatocytes

Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the metabolism, drug-drug interaction and toxicity of drug candidates in a cost-effective manner.

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Human Primary Hepatocytes

Human Primary Fibroblasts

Fibroblast is a type of cell that synthesizes extracellular matrix and collagen, which form the basic framework structure of biological connective tissue in animals and play an important role in tissue repair. As well as being present as fibroblasts, these cells exist in an alternative state, as fibrocytes. Fibroblast is the term used to describe these cells when they are in an activated state. Fibrocyte refers to a state in which cells are less active. The morphology of fibroblasts depends on their function and site of action. Fibroblasts extracted from a particular location can "remember" their original location and function when transplanted to another location in the body.

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Human Primary Fibroblasts

Fluorescent In Situ Hybridization

Fluorescence in situ hybridization (FISH), developed in the 1980s, is a cytogenetic technique using fluorescent probes to bind the chromosome with a high degree of complementarity. It is a powerful and easy method to detect RNA or DNA sequences in cells, tissues, and tumors.

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Fluorescent In Situ Hybridization

Human Adult Stem Cells

Adult stem cells, also known as tissue-specific or somatic stem cells, exist throughout the body from the time an embryo develops. These cells are in a non-specific state, but they are more specialized than embryonic stem cells. They remain in this state until the body needs them for a specific purpose.

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Human Adult Stem Cells

Chromosome Probes

Creative Bioarray is dedicated to offering a portfolio of CABRTM <a href="https://www.creative-bioarray.com/products/cabr-chromosome-probes-list-177.htm">chromosome probes</a> for our customers to detect the amplification, deletion, and translocation of genes and improve chromosome studies, which contain whole chromosome painting probes, centromere probes, subtelomere specific probes, satellite enumeration probes. With years of expertise, our scientists have deep FISH probes knowledge and provide customers a full range of high-quality probe products which cover every human chromosome to best match their research goals.

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Chromosome Probes

Metabolic Disease Models

With increasing incidence of metabolic diseases, these diseases have attracted wide attention in the medical field all over the world. It is estimated that about 20-25% of adults in the world suffer from metabolic diseases. Meanwhile, as a syndrome, metabolic diseases have no single cause. The use of animals in experimentation was and continues to be of great importance in medical research. Animal models of metabolic diseases provide an opportunity to examine correlations among different metabolic parameters. Creative Bioarray provides professional drug testing services using these models.

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Metabolic Disease Models

Transmission Electron Microscopy

Transmission Electron Microscopy (TEM) is a technique which high energy electrons are transmitted through electron transparent samples (~100nm thick). These thin samples interact with the electrons as it passes through it. An image is formed while electron transmitted through the sample. Another technique is called Scanning Transmission Electron Microscopy (STEM), which is a similar method to image samples using electron beam. https://www.creative-bioarray.com/Services/Transmission-Electron-Microscopy.htm

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Transmission Electron Microscopy

ADME service

ADME is short for "absorption, distribution, metabolism, and excretion". The four properties determine the drug level within a body, the drug exposure to tissues, and the metabolic process of a compound, which can help predict the bioavailability and bioactivity of a drug-whether a drug can reach its intended target and confer a therapeutic effect. Therefore, understanding the ADME properties of the compounds is crucial to the drug developing process.

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ADME service

Cell Line Authentication

The human genome is full of repeated DNA sequences which come in various sizes and are classified according to the length of the core repeat units, the number of contiguous repeat units, and/or the overall length of the repeat region. DNA regions with short repeat units (usually 2-6 bp in length) are called Short Tandem Repeats (STR). Creative Bioarray STR profiling is critical for verifying the identity of human cell lines, ensuring the uniqueness of the cell line and detecting laboratory errors such as misidentification and cross-contamination of lines. The sensitivity and high power of discrimination makes our STR analysis an ideal choice for the various types of cell authentication.

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Cell Line Authentication

Exosome Research

Exosomes are cell-derived vesicles (30-100 nm) secreted into various human or animal biofluids and culture medium of cell cultures. Exosomes play a key role in the regulation of important cellular physiological and pathological functions, which are closely associated with almost all disease areas such as cancer, neurodegenerative diseases, diabetes, and cardiovascular diseases. Exosomes carry proteins, lipids, RNAs (microRNA, mRNA, ncRNA), and DNA that may serve as potential biomarkers for disease diagnosis, prognosis, and therapy. https://www.creative-bioarray.com/services/exosome-research-services.htm

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Exosome Research

Herg test

Staffed with a group of experts that have gained years of experience in ion channel safety assays and cardiotoxicity assessment, Creative Bioarray offers hERG safety assay in accordance with the ICH S7B guideline to evaluate compound cardiovascular safety and to support drug development. Inhibition assays of other ion channels are also available. https://www.creative-bioarray.com/Services/hERG-Safety.htm

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Herg test

FFPE tissue block

Creative Bioarray provides a range of normal and diseased tissue blocks. Our high quality tissues are banked under strict and rigorous collection protocols to ensure that both paraffin embedded and frozen tissues are all well characterized, clinically annotated tissues needed for critical experiments. https://www.creative-bioarray.com/products/tissue-blocks-list-19.htm?page=1

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FFPE tissue block

Endothelial Cells

Endothelial cells are cells that line the inner surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. The endothelial cells serve as a permeable barrier to regulate the passage of substances between blood-stream and surrounding tissue. In basic research, endothelial cells are critical in applications related to wound healing, angiogenesis, blood brain barrier (BBB), inflammatory processes, diabetes and other cardiovascular diseases. https://www.creative-bioarray.com/filter/endothelial-cell-and-media-10.html

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Endothelial Cells

Primary Cell

Creative Bioarray offers 35 human cell systems with over 160 different cell types. Moreover, we also provide our customers primary cells from over 13 types of other animals. These cells taken from living tissue are extremely accurate as they are literally coming from the source and are available from many sources on the human body. These living samples can give extremely accurate information about the cells in vivo and give relevant information regarding the living systems. https://www.creative-bioarray.com/products/primary-cell-types-list-14.htm?page=1

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Primary Cell

Huh7

Creative Bioarray maintains various human and animal tumor cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray consistently attains the highest standards and uses the most reliable procedures to verify every cell line. Every study is different and requires different cells and samples. Creative Bioarray has the largest selection of organ specific and cancer related tumor cells available. Every sample has its own description and origin included so you know exactly what you are receiving with us. https://www.creative-bioarray.com/Huh7-CSC-C9441L-item-39686.htm

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Huh7

STR DNA profile

Creative Bioarray STR profiling is critical for verifying the identity of human cell lines, ensuring uniqueness of the cell line and detecting laboratory errors such as misidentification and cross-contamination of lines. The sensitivity and high power of discrimination makes our STR analysis an ideal choice for the various types of cell authentication. https://www.creative-bioarray.com/Services/Short-Tandem-Repeat-Analysis.htm

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STR DNA profile

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STR DNA profile

Bone Marrow Mononuclear Cells

Bone Marrow-Mononuclear Cells are isolated by diluting bone marrow with phosphatebuffered saline and using density gradient separation techniques. After centrifugation, the Mononuclear Cells layer is collected. Mononuclear Cells can be processed further to isolate various subpopulations. https://www.creative-bioarray.com/Bone-Marrow-Mononuclear-Cells-CSC-C4567X-item-2287.htm

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Bone Marrow Mononuclear Cells

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Bone Marrow Mononuclear Cells

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Bone Marrow Mononuclear Cells